Stem cell pharmacogenomics: a reality check on stem cell therapy

Curr Opin Mol Ther. 2005 Dec;7(6):551-6.

Abstract

Widespread applications of stem cell-based therapies in the clinic are being reported, yet there is a surprising lack of resolution of the factors that lead to failure of such therapies on a long-term basis. While classical pharmacogenomics aids the prediction of drug responses in an individual based on genetic variation and pharmacological responses, stem cell therapy involves an additional dimension of host-donor cell interactions and adaptability. We propose the development of concise guidelines based on pharmacogenetic and donor/host-related cellular factors studied more extensively in larger data sets, and used in prospective studies to individualize stem cell therapy.

Publication types

  • Review

MeSH terms

  • Graft vs Host Disease / complications
  • Graft vs Host Disease / therapy
  • Humans
  • Immunosuppression
  • Pharmacogenetics*
  • Stem Cell Transplantation*
  • Stem Cells / metabolism*