Development of supersaturatable self-emulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs

Expert Opin Drug Deliv. 2006 Jan;3(1):97-110. doi: 10.1517/17425247.3.1.97.

Abstract

The supersaturatable self-emulsifying drug delivery system (S-SEDDS) represents a new thermodynamically stable formulation approach wherein it is designed to contain a reduced amount of a surfactant and a water-soluble cellulosic polymer (or other polymers) to prevent precipitation of the drug by generating and maintaining a supersaturated state in vivo. The S-SEDDS formulations can result in enhanced oral absorption as compared with the related self-emulsifying drug delivery systems (SEDDS) formulation and the reduced surfactant levels may minimise gastrointestinal surfactant side effects.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Biological Availability
  • Chemistry, Pharmaceutical
  • Drug Delivery Systems*
  • Emulsions
  • Humans
  • Intestinal Absorption*
  • Pharmaceutical Preparations / metabolism
  • Polymers
  • Solubility
  • Surface-Active Agents

Substances

  • Emulsions
  • Pharmaceutical Preparations
  • Polymers
  • Surface-Active Agents