CGRP as a marker of the climbing fibers during the development of the cerebellum in the rat

Ann N Y Acad Sci. 1992 Jun 30:657:461-3. doi: 10.1111/j.1749-6632.1992.tb22800.x.

Abstract

Olivary fibers express CGRP-LI until the nest phase of their development and never in the next postnatal steps, that is, the "capuchon" stage. Together with other results presented in this volume regarding the postnatal development of CGRP binding sites in the cerebellar cortex, these immunohistologic findings suggest a role for CGRP in reshaping connectivity and in synapse stabilization of cerebellar circuitry during postnatal development.

MeSH terms

  • Aging / physiology*
  • Animals
  • Animals, Newborn
  • Biomarkers
  • Calcitonin Gene-Related Peptide / analysis*
  • Cerebellar Cortex / cytology
  • Cerebellar Cortex / growth & development
  • Cerebellum / cytology
  • Cerebellum / growth & development*
  • Immunoenzyme Techniques
  • Nerve Fibers / physiology*
  • Nerve Fibers / ultrastructure
  • Rats
  • Rats, Inbred Strains

Substances

  • Biomarkers
  • Calcitonin Gene-Related Peptide