The use of an oral contraceptive containing ethinylestradiol and drospirenone in an extended regimen over 126 days

Contraception. 2006 Jan;73(1):34-40. doi: 10.1016/j.contraception.2005.06.068. Epub 2005 Sep 26.


Objective: To assess the bleeding profile, acceptance and safety of an extended 126-day regimen of the oral contraceptive Yasmin [30 microg ethinylestradiol (EE) and 3 mg drospirenone (DRSP)].

Methods: Using daily diaries, 177 women recorded bleeding events throughout the 126-day cycle. At end of treatment, the women completed questionnaires reflecting their satisfaction with the extended regimen. A subset of 30 women underwent endometrial histology sampling after completion of the extended regimen.

Results: Of 177 women assigned to the extended regimen, 80.8% completed the extended 126-day regimen. Approximately 40% of the women reported complete absence of bleeding, while in 60% a shift towards less intense bleeding was observed. The first onset of bleeding occurred after a median of 99.0 days into the extended cycle. The acceptance of the extended regimen was high, with 68.4% of the women expressing satisfaction. The general safety profile with the extended use was comparable to that seen with the conventional 21+7-day regimen. All endometrial biopsies with sufficient material for analysis were normal and supported the endometrial safety of the extended regimen.

Conclusion: This study showed that the continuous use of a 30-microg EE and 3-mg DRSP formulation over 126 days was safe, efficacious, well accepted by the users and resulted in a considerable reduction of bleeding.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Androstenes / administration & dosage*
  • Contraceptives, Oral / administration & dosage*
  • Contraceptives, Oral / adverse effects
  • Ethinyl Estradiol / administration & dosage*
  • Female
  • Humans
  • Menstrual Cycle
  • Patient Satisfaction
  • Prospective Studies
  • Time Factors
  • Uterine Hemorrhage / epidemiology


  • Androstenes
  • Contraceptives, Oral
  • Ethinyl Estradiol
  • drospirenone