Case Reports
doi: 10.1056/NEJMoa054512.
Oseltamivir resistance during treatment of influenza A (H5N1) infection
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- PMID: 16371632
- DOI: 10.1056/NEJMoa054512
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Case Reports
Oseltamivir resistance during treatment of influenza A (H5N1) infection
N Engl J Med.
.
Free article
Abstract
Influenza A (H5N1) virus with an amino acid substitution in neuraminidase conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese patients during oseltamivir treatment. Both patients died of influenza A (H5N1) virus infection, despite early initiation of treatment in one patient. Surviving patients had rapid declines in the viral load to undetectable levels during treatment. These observations suggest that resistance can emerge during the currently recommended regimen of oseltamivir therapy and may be associated with clinical deterioration and that the strategy for the treatment of influenza A (H5N1) virus infection should include additional antiviral agents.
Copyright 2005 Massachusetts Medical Society.
Comment in
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Oseltamivir resistance--disabling our influenza defenses.N Engl J Med. 2005 Dec 22;353(25):2633-6. doi: 10.1056/NEJMp058291. N Engl J Med. 2005. PMID: 16371626 No abstract available.
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Oseltamivir resistance in influenza A (H5N1) infection.N Engl J Med. 2006 Mar 30;354(13):1423-4; author reply 1423-4. doi: 10.1056/NEJMc060077. N Engl J Med. 2006. PMID: 16571890 No abstract available.
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