Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk

J Dent Res. 2006 Jan;85(1):74-8. doi: 10.1177/154405910608500113.


Prior studies of a link between periodontal and cardiovascular disease have been limited by being predominantly observational. We used a treatment intervention model to study the relationship between periodontitis and systemic inflammatory and thrombotic cardiovascular indicators of risk. We studied 67 adults with advanced periodontitis requiring full-mouth tooth extraction. Blood samples were obtained: (1) at initial presentation, immediately prior to treatment of presenting symptoms; (2) one to two weeks later, before all teeth were removed; and (3) 12 weeks after full-mouth tooth extraction. After full-mouth tooth extraction, there was a significant decrease in C-reactive protein, plasminogen activator inhibitor-1 and fibrinogen, and white cell and platelet counts. This study shows that elimination of advanced periodontitis by full-mouth tooth extraction reduces systemic inflammatory and thrombotic markers of cardiovascular risk. Analysis of the data supports the hypothesis that treatment of periodontal disease may lower cardiovascular risk, and provides a rationale for further randomized studies.

MeSH terms

  • Adult
  • C-Reactive Protein / analysis
  • Cohort Studies
  • Diabetes Mellitus / blood
  • Female
  • Fibrinogen / analysis
  • Follow-Up Studies
  • Heart Diseases / blood*
  • Humans
  • Hyperlipidemias / blood
  • Hypertension / blood
  • Inflammation Mediators / blood*
  • Leukocyte Count
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Periodontitis / therapy*
  • Plasminogen Activator Inhibitor 1 / blood
  • Platelet Count
  • Risk Factors
  • Smoking / blood
  • Thrombosis / blood*
  • Tissue Plasminogen Activator / blood
  • Tooth Extraction*


  • Inflammation Mediators
  • Plasminogen Activator Inhibitor 1
  • Fibrinogen
  • C-Reactive Protein
  • Tissue Plasminogen Activator