Hemodynamic effects of di-sec-butyl phenol, an anesthetic substituted phenol

Pharmacology. 2006;76(3):117-22. doi: 10.1159/000090501. Epub 2005 Dec 22.

Abstract

Dose- and age-related hemodynamic effects were determined for an anesthetic substituted phenol, 2,6-di-sec-butyl phenol (DSB). DSB, 7.5 mg/kg, induced hypnosis in young rabbits and increased mean blood pressure to 170 +/- 14% and heart rate to 150 +/- 21% of control values. In elderly rabbits, 7.5 mg/kg DSB induced hypnosis, had no effect on blood pressure, but increased the heart rate to 130 +/- 2% of control. After ganglionic blockade with hexamethonium, 7.5 mg/kg DSB caused a decline in mean blood pressure (71 +/- 5% of control) without change in heart rate. DSB increased norepinephrine release from SH-SY5Y cells, a human neuroblastoma cell line (5.4 +/- 1.7% vs. 3.5 +/- 0.3%). DSB produced age-dependent elevation of mean blood pressure in rabbits, probably by causing release of catecholamines from the sympathetic nervous system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Anesthetics / chemistry
  • Anesthetics / pharmacology*
  • Animals
  • Blood Pressure / drug effects*
  • Butanes / administration & dosage
  • Butanes / chemistry
  • Butanes / pharmacology*
  • Cell Line, Tumor
  • Dimethyl Sulfoxide / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Ganglionic Blockers / pharmacology
  • Heart Rate / drug effects*
  • Hexamethonium / pharmacology
  • Humans
  • Injections, Intravenous
  • Norepinephrine / metabolism
  • Phenols / administration & dosage
  • Phenols / chemistry
  • Phenols / pharmacology*
  • Potassium / pharmacology
  • Rabbits
  • Time Factors
  • Tritium

Substances

  • Anesthetics
  • Butanes
  • Ganglionic Blockers
  • Phenols
  • di-sec-butyl phenol
  • Tritium
  • Hexamethonium
  • Potassium
  • Norepinephrine
  • Dimethyl Sulfoxide