Uric acid and the kidney: urate transport, stone disease and progressive renal failure

Curr Pharm Des. 2005;11(32):4153-9. doi: 10.2174/138161205774913219.

Abstract

In this brief review and update, we try to cover recent developments in our understanding of uric acid transport by the kidney, the contribution of uric acid to renal stone disease, its potential role in progressive renal failure and, most recently, the novel and as yet unexplained link between the urinary glycoprotein Tamm-Horsfall protein (uromodulin) and hyperuricaemia and two inherited forms of renal disease with chronic renal failure.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Carrier Proteins / physiology
  • Humans
  • Hyperuricemia / complications
  • Kidney / metabolism*
  • Kidney Calculi / etiology*
  • Organic Anion Transport Protein 1 / physiology
  • Organic Anion Transporters / physiology
  • Organic Cation Transport Proteins
  • Renal Insufficiency / etiology*
  • Uric Acid / metabolism*

Substances

  • Carrier Proteins
  • Organic Anion Transport Protein 1
  • Organic Anion Transporters
  • Organic Cation Transport Proteins
  • SLC22A12 protein, human
  • Uric Acid