Smaller volume of anterior cingulate cortex in abuse-related posttraumatic stress disorder

J Affect Disord. 2006 Feb;90(2-3):171-4. doi: 10.1016/j.jad.2005.11.006. Epub 2006 Jan 10.


Objective: The anterior cingulate cortex (ACC) plays an important role in emotion, and studies in animals have shown changes in ACC structure with early life stress. The purpose of this study was to measure volume of the ACC in PTSD.

Method: Magnetic resonance imaging (MRI) was used to measure ACC volume in 8 subjects with abuse-related PTSD and 13 healthy subjects without PTSD. ACC volume included Brodmann's area [BA] 24 and 32.

Results: Right ACC volume in PTSD patients was significantly smaller than in non-PTSD subjects.

Conclusion: These results are consistent with smaller ACC volume in PTSD.

MeSH terms

  • Adult
  • Atrophy
  • Child
  • Child Abuse / diagnosis*
  • Child Abuse / psychology
  • Dominance, Cerebral / physiology
  • Emotions / physiology
  • Female
  • Gyrus Cinguli / pathology*
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Reference Values
  • Stress Disorders, Post-Traumatic / diagnosis*
  • Stress Disorders, Post-Traumatic / pathology
  • Stress Disorders, Post-Traumatic / psychology