Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features

Br J Cancer. 1992 Jul;66(1):131-5. doi: 10.1038/bjc.1992.229.

Abstract

In a cytogenetic study of breast cancer biopsies, clonal abnormalities of chromosome 1p were identified in 56% (14) of 25 informative patients. Translocations predominated, involving 1p22 (n = 1), 1p35 (n = 1) or 1p36 (n = 10) breakpoints. Chromosome 1p abnormalities were associated with estrogen receptor (ER) negativity (P = 0.03, 2-tailed Fisher Exact Probability test), high histological grade (P = 0.02, 2-tailed Mann-Whitney U-test) and an unfavourable Melbourne Prognostic Score (NEPA P = 0.02, SEPA P = 0.04, 2-tailed Mann-Whitney U-tests). These findings are consistent with the possibility that a gene located on chromosome 1p is implicated in tumour progression.

MeSH terms

  • Biomarkers, Tumor / analysis
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery
  • Chromosome Aberrations
  • Chromosome Disorders
  • Chromosomes, Human, Pair 1*
  • Female
  • Gene Rearrangement*
  • Humans
  • Karyotyping
  • Neoplasm Staging
  • Prognosis
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis
  • Tumor Cells, Cultured

Substances

  • Biomarkers, Tumor
  • Receptors, Estrogen
  • Receptors, Progesterone