Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response

Cancer Lett. 2006 Mar 8;234(1):40-50. doi: 10.1016/j.canlet.2005.06.050. Epub 2005 Dec 27.

Abstract

Among the ABC proteins, some members including ABCB1, ABCC1, ABCC2 and ABCG2 are believed to contribute to multidrug resistance of cancer chemotherapy. In addition, the broad substrate-specificity and apical localization of the ABCB1 and ABCC2 in mucosal epithelium of intestine and hepatocyte give them a protective role against xenobiotics. The inter-individual variations in activity and expression levels of ABCB1 and ABCC2, thus, might affect on drug response and response to toxic substrates. In this review, I focus on (1) physiological and toxicological relevance of ABCB1 and ABCC2, and on (2) genetic variations of ABCB1 and ABCC2 genes and their association with biochemical function, expression level and tumor incidence.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • ATP-Binding Cassette Transporters / genetics*
  • ATP-Binding Cassette, Sub-Family C Proteins / genetics*
  • Biological Transport
  • Drug Resistance, Multiple*
  • Drug Resistance, Neoplasm
  • Humans
  • Membrane Transport Proteins / genetics*
  • Multidrug Resistance-Associated Protein 2
  • Neoplasms / drug therapy*
  • Pharmaceutical Preparations
  • Pharmacogenetics
  • Polymorphism, Single Nucleotide*

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • ATP-Binding Cassette Transporters
  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Protein 2
  • ATP-Binding Cassette, Sub-Family C Proteins
  • Pharmaceutical Preparations
  • ABCC2 protein, human
  • Abcb1b protein, mouse