Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 16 (1), 51-9

Balancing Cell Adhesion and Wnt Signaling, the Key Role of Beta-Catenin

Affiliations
Review

Balancing Cell Adhesion and Wnt Signaling, the Key Role of Beta-Catenin

Felix H Brembeck et al. Curr Opin Genet Dev.

Abstract

Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell-cell adhesion and gene transcription. The armadillo repeat protein beta-catenin is an important integrator of both processes. Beta-catenin acts in the Wnt signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. Beta-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of beta-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell-cell adhesion and to the increased transcription of Wnt target genes.

Similar articles

See all similar articles

Cited by 238 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback