Cord insulin and C-peptide--distribution in an unselected population

Br J Obstet Gynaecol. 1992 Jun;99(6):512-5. doi: 10.1111/j.1471-0528.1992.tb13793.x.


Objective: To assess the distribution of cord blood insulin in an unselected population, and examine its relation to birthweight centiles.

Setting: District General Hospital in Nottinghamshire.

Subjects: 209 unselected singleton births.

Mean outcome measure: Cord blood insulin; cord blood C-peptide; birthweight centiles.

Results: Hyperinsulinaemic babies (greater than 97th centile for cord insulin) were found at all birthweight centiles. 15% of high birthweight babies were hyperinsulinaemic. For low birthweight babies, the distribution of cord insulin/C-peptide was skewed indicating a high number of low values. Hypoinsulinaemic babies were present up to the 50th centile for birthweight.

Conclusions: Abnormalities of fetal insulinisation may be found in babies of all birthweights.

MeSH terms

  • Birth Weight*
  • C-Peptide / blood*
  • Fetal Blood*
  • Humans
  • Infant, Newborn
  • Insulin / blood*
  • Neonatal Screening / methods
  • Radioimmunoassay


  • C-Peptide
  • Insulin