NKG2D in NK and T cell-mediated immunity

J Clin Immunol. 2005 Nov;25(6):534-40. doi: 10.1007/s10875-005-8786-4.


One of the best characterized NK cell receptors is NKG2D, a highly conserved C-type lectin-like membrane glycoprotein expressed on essentially all NK cells, as well as on gammadelta-TcR+ T cells and alphabeta-TcR+ CD8+ T cells, in humans and mice. Here we review recent studies implicating NKG2D in T cell and NK cell-mediated immunity to viruses and tumors, and its potential role in autoimmune diseases and allogeneic bone marrow transplantation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Graft Rejection / immunology
  • Graft Rejection / pathology
  • Humans
  • Immunity, Cellular*
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism*
  • NK Cell Lectin-Like Receptor Subfamily K / chemistry
  • NK Cell Lectin-Like Receptor Subfamily K / physiology*
  • Neoplasms / immunology
  • Neoplasms / pathology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism*


  • NK Cell Lectin-Like Receptor Subfamily K