The SRF and MCM1 transcription factors

Curr Opin Genet Dev. 1992 Apr;2(2):221-6. doi: 10.1016/s0959-437x(05)80277-1.


The mammalian transcription factor SRF (serum-response factor) and the related Saccharomyces cerevisiae transcription factor MCM1 are the prototypes of a new class of dimeric DNA-binding proteins. Their function is regulated in part by the interactions of their DNA-binding domains with accessory proteins. Recent work has advanced the functional characterization of the contributions of SRF and MCM1, and their accessory proteins to transcriptional activation.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA-Binding Proteins* / chemistry
  • DNA-Binding Proteins* / physiology
  • Fungal Proteins* / chemistry
  • Minichromosome Maintenance 1 Protein
  • Molecular Sequence Data
  • Nuclear Proteins* / chemistry
  • Nuclear Proteins* / physiology
  • Serum Response Factor
  • Transcription Factors* / chemistry
  • Transcription Factors* / physiology


  • DNA-Binding Proteins
  • Fungal Proteins
  • Minichromosome Maintenance 1 Protein
  • Nuclear Proteins
  • Serum Response Factor
  • Transcription Factors