[The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract]

Zhongguo Zhong Yao Za Zhi. 2005 Sep;30(18):1458-61.
[Article in Chinese]

Abstract

Objective: To study the pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract.

Method: The blood sample were obtained at 0,0.083,0.5,1,1.5,2,3,4,5,7,10 h after a single dose oral administration of rhubarb (50 mg x kg(-1)). The plasma rhein concentration was determined by HPLC. The pharmacokinetics of rhein were analysed by 3P97 program.

Result: The absorption of rhein was very fastafter oral administration of rhubarb extract in the healthy volunteers. The main pharmacokinetic parameters of rhein were C(max) (3.20 +/- 1.08) microg x mL(-1); t(max) (1.03 +/- 0.41) h; t(1/2alpha) (0.21 +/- 0.02) h; t(1/2beta) (2.68 +/- 1.09) h; MRT(5.31 +/- 1.78) h; AUC(0-infinity) (1 573.08 +/- 366.48) microg x mL(-1) min(-1), respectively.

Conclusion: Rhein could be absorbed rapidly and its pharmacokinetics was consistent with two-compartment model.

Publication types

  • English Abstract

MeSH terms

  • Administration, Oral
  • Adult
  • Anthraquinones / blood
  • Anthraquinones / pharmacokinetics*
  • Area Under Curve
  • Chromatography, High Pressure Liquid
  • Drugs, Chinese Herbal / administration & dosage
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacokinetics*
  • Female
  • Humans
  • Male
  • Plants, Medicinal* / chemistry
  • Rheum* / chemistry

Substances

  • Anthraquinones
  • Drugs, Chinese Herbal
  • rhein