LOCATE: a mouse protein subcellular localization database

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D213-7. doi: 10.1093/nar/gkj069.


We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were determined by a high-throughput, immunofluorescence-based assay and by manually reviewing >1700 peer-reviewed publications. LOCATE represents the first effort to catalogue the experimentally verified subcellular location and membrane organization of mammalian proteins using a high-throughput approach and provides localization data for approximately 40% of the mouse proteome. It is available at http://locate.imb.uq.edu.au.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Databases, Protein*
  • Internet
  • Membrane Proteins / analysis*
  • Membrane Proteins / chemistry
  • Mice
  • Protein Isoforms / analysis
  • Protein Isoforms / chemistry
  • Proteome / analysis*
  • Proteome / chemistry
  • User-Computer Interface


  • Membrane Proteins
  • Protein Isoforms
  • Proteome