FlyRNAi: the Drosophila RNAi screening center database

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D489-94. doi: 10.1093/nar/gkj114.


RNA interference (RNAi) has become a powerful tool for genetic screening in Drosophila. At the Drosophila RNAi Screening Center (DRSC), we are using a library of over 21,000 double-stranded RNAs targeting known and predicted genes in Drosophila. This library is available for the use of visiting scientists wishing to perform full-genome RNAi screens. The data generated from these screens are collected in the DRSC database ( in a flexible format for the convenience of the scientist and for archiving data. The long-term goal of this database is to provide annotations for as many of the uncharacterized genes in Drosophila as possible. Data from published screens are available to the public through a highly configurable interface that allows detailed examination of the data and provides access to a number of other databases and bioinformatics tools.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Computational Biology
  • Databases, Genetic*
  • Drosophila / genetics*
  • Gene Library
  • Genome, Insect
  • Internet
  • RNA Interference*
  • RNA, Double-Stranded / genetics
  • Software
  • User-Computer Interface


  • RNA, Double-Stranded