The Serotonergic System and Its Role in Cocaine Addiction

Pharmacol Rep. Nov-Dec 2005;57(6):685-700.

Abstract

Cocaine is an alkaloid with psychostimulant action and high addictive potential. It possesses high affinity for the transporters of dopamine, serotonin (5-HT) and noradrenaline, and blocks reuptake of the above-mentioned monoamines. The present review summarized the contribution of 5-HT neurotransmitter system to rewarding and aversive properties of cocaine, to cocaine withdrawal and its long-term abuse. The present state of knowledge of 5-HT neurotransmission justifies the opinion that pharmacological manipulation in the 5-HT system may efficiently counteract the effects of cocaine withdrawal and prevent reinstatement of its abuse.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Central Nervous System Stimulants / adverse effects*
  • Central Nervous System Stimulants / metabolism
  • Cocaine / adverse effects*
  • Cocaine / metabolism
  • Cocaine-Related Disorders / metabolism*
  • Dopamine Plasma Membrane Transport Proteins / metabolism
  • Humans
  • Norepinephrine Plasma Membrane Transport Proteins / metabolism
  • Receptors, Serotonin / metabolism
  • Serotonin / metabolism*
  • Serotonin Plasma Membrane Transport Proteins / metabolism
  • Substance Withdrawal Syndrome / metabolism*
  • Synaptic Transmission

Substances

  • Central Nervous System Stimulants
  • Dopamine Plasma Membrane Transport Proteins
  • Norepinephrine Plasma Membrane Transport Proteins
  • Receptors, Serotonin
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Cocaine