Cell-matrix response in tendon injury

Clin Sports Med. 1992 Jul;11(3):533-78.


The healing response after tendon injury is defined by cell matrix adaptive capability. There are distinct macrotraumatic and microtraumatic injury patterns and a spectrum of pathologic responses from inflammation to tissue degeneration, as characterized by the tendinosis phenomenon. Epigenetic and genetic factors govern recovery from tendon injury. The potential for future modulation of injury repair by protein mediators or growth factors appears promising.

Publication types

  • Review

MeSH terms

  • Achilles Tendon / blood supply
  • Achilles Tendon / pathology
  • Achilles Tendon / ultrastructure
  • Acute Disease
  • Athletic Injuries / physiopathology*
  • Extracellular Matrix / pathology
  • Extracellular Matrix / physiology*
  • Humans
  • Microscopy, Electron
  • Pain / etiology
  • Tendinopathy / physiopathology
  • Tendon Injuries / pathology
  • Tendon Injuries / physiopathology*
  • Terminology as Topic
  • Wound Healing / physiology