'What controls aqueous humour outflow resistance?'

Exp Eye Res. 2006 Apr;82(4):545-57. doi: 10.1016/j.exer.2005.10.011. Epub 2006 Jan 4.


The bulk of aqueous humour outflow resistance is generated in or near the inner wall endothelium of Schlemm's canal in normal eyes, and probably also in glaucomatous eyes. Fluid flow through this region is controlled by the location of the giant vacuoles and pores found in cells of the endothelium of Schlemm's canal, but the flow resistance itself is more likely generated either in the extracellular matrix of the juxtacanalicular connective tissue or the basement membrane of Schlemm's canal. Future studies utilizing in vitro perfusion studies of inner wall endothelial cells may give insights into the process by which vacuoles and pores form in this unique endothelium and why inner wall pore density is greatly reduced in glaucoma.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aqueous Humor / physiology*
  • Basement Membrane / physiopathology
  • Connective Tissue / physiology
  • Endothelium / physiology
  • Extracellular Matrix / physiology
  • Eye / ultrastructure
  • Glaucoma, Open-Angle / physiopathology
  • Humans
  • Microscopy, Electron
  • Sclera / blood supply
  • Trabecular Meshwork / physiology
  • Vacuoles
  • Veins