Benign breast diseases associated with cyclosporine therapy in renal transplant recipients

Transplant Proc. 2005 Dec;37(10):4315-9. doi: 10.1016/j.transproceed.2005.10.111.


Purpose: Our aim was to correlate the radiologic characteristics of cyclosporine-induced benign breast diseases with clinical and pathologic findings.

Materials and methods: The clinical, mammographic, and ultrasonographic records of 33 female renal transplant recipients who received cyclosporine were retrospectively reviewed. Eleven patients had 46 breast masses on ultrasonography. We performed core needle biopsies on 20 masses and reviewed the pathologic findings.

Results: Among 33 female renal transplant recipients, 11 (33%) had 46 benign breast lesions detected on ultrasonography. We performed core needle biopsies on 20 of the 46 masses. On pathologic examination, 12 were fibroadenomas, 6 showed fibrocystic changes, and 2 revealed dense fibrosis. Regardless of the final pathologic diagnosis, more than half of the lesions revealed severe lymphatic and venular swellings. Among 11 patients with breast lesions on ultrasonography, 10/11 (91%) showed multiplicity, and 7/11 (64%) bilaterality. Mammographically, patients with breast lesions revealed heterogeneous or extremely dense breast patterns, and 8 of 11 patients, circumscribed masses. Twenty-two patients without breast lesions showed scattered fibroglandular densities (n = 7), or heterogeneously dense (n = 11) or extremely dense (n = 4) breast patterns, and 3 of 22 patients showed vague or asymmetric densities that needed further evaluation.

Conclusion: The development of new breast lesions in patients after renal transplantation should suggest a diagnosis of cyclosporine-induced benign breast disease including fibroadenoma, fibrocystic changes, and dense fibrosis.

MeSH terms

  • Adult
  • Biopsy, Needle
  • Breast Diseases / chemically induced*
  • Breast Diseases / classification
  • Breast Diseases / diagnostic imaging
  • Breast Diseases / pathology
  • Cyclosporine / adverse effects*
  • Female
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Kidney Transplantation / immunology*
  • Mammography
  • Middle Aged
  • Retrospective Studies
  • Ultrasonography


  • Immunosuppressive Agents
  • Cyclosporine