Survival beyond 10 years following heart transplantation: The Cleveland Clinic Foundation experience

Transplant Proc. 2005 Dec;37(10):4509-12. doi: 10.1016/j.transproceed.2005.10.021.


Background: Long-term survival after heart transplantation is a desirable although challenging goal.

Methods: We analyzed clinical outcomes in the cohort of 170 patients who have undergone heart transplantation at The Cleveland Clinic Foundation and survived >10 years.

Results: We found 10-year and 15-year survival rates of 54% and 41%, respectively, in these patients, but there was also a high incidence of complications, such as hypertension, renal dysfunction, transplant vasculopathy, and malignancy.

Conclusions: Long-term survival following cardiac transplantation is possible although complications are frequent. Beyond 10 years, malignancy is a major cause of death.

MeSH terms

  • Adult
  • Cohort Studies
  • Female
  • Graft Rejection / epidemiology
  • Heart Transplantation / immunology
  • Heart Transplantation / mortality
  • Heart Transplantation / physiology
  • Heart Transplantation / statistics & numerical data*
  • Humans
  • Immunosuppression Therapy
  • Male
  • Middle Aged
  • Retrospective Studies
  • Survival Analysis
  • Survivors / statistics & numerical data*
  • Time Factors
  • Tissue Donors / statistics & numerical data