MRP2 and 3 in health and disease

Cancer Lett. 2006 Mar 8;234(1):51-61. doi: 10.1016/j.canlet.2005.05.051. Epub 2006 Jan 4.

Abstract

MRPs are membrane proteins transporting organic anions at the expense of ATP hydrolysis. MRP2 is known to be a major transporter of organic anions from the liver into bile. We discuss recent results showing allosteric control of human but not rat MRP2. MRP3 has been considered a major player in bile salt metabolism, but our recent results with Mrp3 KO mice do not support this. Instead, we have found a role for MRP3 in the cellular export of drug-glucuronide conjugates. We discuss problems in extrapolating results obtained for murine MRPs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bile Acids and Salts / metabolism*
  • Biological Transport
  • Glucuronides / metabolism*
  • Humans
  • Liver Diseases / metabolism*
  • Liver Diseases / pathology
  • Membrane Transport Proteins / physiology*
  • Multidrug Resistance-Associated Proteins / physiology*

Substances

  • Bile Acids and Salts
  • Glucuronides
  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Proteins
  • multidrug resistance-associated protein 3
  • multidrug resistance-associated protein 2