Positive selection can create false hotspots of recombination

Genetics. 2006 Mar;172(3):2011-4. doi: 10.1534/genetics.105.052183. Epub 2005 Dec 30.

Abstract

Simulations of positive directional selection, under parameter values appropriate for approximating human genetic diversity and rates of recombination, reveal that the effects of strong selective sweeps on patterns of linkage disequilibrium (LD) mimic the pattern expected with recombinant hotspots.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation*
  • Humans
  • Linkage Disequilibrium
  • Meiosis* / genetics
  • Models, Genetic
  • Recombination, Genetic*
  • Selection, Genetic
  • Species Specificity