Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome

Arch Pediatr Adolesc Med. 2006 Jan;160(1):65-9. doi: 10.1001/archpedi.160.1.65.


Background: Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic symptoms during adolescence. At least one third of adults with TS have comorbid obsessive-compulsive disorder (OCD).

Objectives: To clarify the clinical course of tic and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolescence and early adulthood.

Design: Prospective cohort study.

Setting: Yale Child Study Center tic and OCD outpatient specialty clinic.

Participants: Forty-six children with TS who received a structured clinical evaluation prior to age 14 years.

Main outcome measures: Expert-rated tic and OCD symptom severity at follow-up interview an average of 7.6 years later (range, 3.8-12.8 years).

Results: Eighty-five percent of subjects reported a reduction in tic symptoms during adolescence. Only increased tic severity in childhood was associated with increased tic severity at follow-up. The average age at worst-ever tic severity was 10.6 years. Forty-one percent of patients with TS reported at one time experiencing at least moderate OCD symptoms. Worst-ever OCD symptoms occurred approximately 2 years later than worst-ever tic symptoms. Increased childhood IQ was strongly associated with increased OCD severity at follow-up.

Conclusion: Obsessive-compulsive disorder symptoms in children with TS became more severe at a later age and were more likely to persist than tic symptoms.

MeSH terms

  • Adolescent
  • Adrenergic alpha-Agonists / therapeutic use
  • Adult
  • Antipsychotic Agents / therapeutic use
  • Attention Deficit Disorder with Hyperactivity / complications
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Bipolar Disorder / complications
  • Bipolar Disorder / drug therapy
  • Child
  • Depressive Disorder / complications
  • Depressive Disorder / drug therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Intelligence Tests
  • Male
  • Obsessive-Compulsive Disorder / complications*
  • Obsessive-Compulsive Disorder / drug therapy
  • Prospective Studies
  • Schizophrenia / complications
  • Schizophrenia / drug therapy
  • Serotonin Uptake Inhibitors / therapeutic use
  • Severity of Illness Index*
  • Tic Disorders / complications*
  • Tic Disorders / drug therapy
  • Tourette Syndrome / complications*
  • Tourette Syndrome / drug therapy


  • Adrenergic alpha-Agonists
  • Antipsychotic Agents
  • Serotonin Uptake Inhibitors