Hyperprolinemia is not associated with childhood onset schizophrenia

Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 5;141B(2):192. doi: 10.1002/ajmg.b.30263.

Abstract

In a previous report [Jacquet et al., 2005] we have shown that mild to moderate hyperprolinemia resulting from several alterations (either a complete deletion or missense mutations) of the proline dehydrogenase (PRODH) gene located on chromosome 22q11 is a risk factor for schizoaffective disorder but not for DSM3 R schizophrenia or bipolar disorder. We now report that hyperprolinemia is not associated with childhood onset schizophrenia (COS).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Child
  • DNA Mutational Analysis
  • Female
  • Humans
  • Male
  • Mutation, Missense
  • Proline / blood*
  • Proline Oxidase / genetics*
  • Proline Oxidase / metabolism
  • Schizophrenia / blood
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*

Substances

  • Proline
  • Proline Oxidase