Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis

J Drug Target. 2005 Dec;13(10):555-61. doi: 10.1080/10611860500422958.


In the present study, we evaluated antimicrobial activity of clove oil against a range of fungal pathogens including that responsible for urogenital infection. Clove oil was found to possess strong antifungal activity against opportunistic fungal pathogens such as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, etc. The oil was found to be extremely successful in the treatment of experimental murine vaginitis in model animals. On evaluating various formulations, topical administration of the liposomized clove oil was found to be most effective against treatment of vaginal candidiasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intravaginal
  • Animals
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Aspergillus fumigatus / drug effects
  • Candida albicans / drug effects
  • Candidiasis, Vulvovaginal / drug therapy*
  • Candidiasis, Vulvovaginal / microbiology
  • Clove Oil / administration & dosage
  • Clove Oil / pharmacology
  • Clove Oil / therapeutic use*
  • Cryptococcus neoformans / drug effects
  • Emulsions
  • Female
  • Liposomes
  • Mice
  • Microbial Sensitivity Tests


  • Antifungal Agents
  • Clove Oil
  • Emulsions
  • Liposomes