Identification of the target self-antigens in reperfusion injury

J Exp Med. 2006 Jan 23;203(1):141-52. doi: 10.1084/jem.20050390. Epub 2006 Jan 3.


Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Autoantigens / immunology*
  • Autoimmunity
  • Capillary Permeability
  • Hindlimb
  • Homeodomain Proteins / genetics
  • Immunity, Innate
  • Immunoglobulin M / immunology*
  • Ischemia
  • Jejunum / immunology
  • Jejunum / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Skeletal / immunology
  • Muscle, Skeletal / pathology
  • Nonmuscle Myosin Type IIA / immunology*
  • Reperfusion Injury / immunology*


  • Autoantigens
  • Homeodomain Proteins
  • Immunoglobulin M
  • RAG-1 protein
  • Nonmuscle Myosin Type IIA