Primary intraocular lymphoma arising during methotrexate treatment of temporal arteritis

Can J Ophthalmol. 2005 Oct;40(5):585-92. doi: 10.1016/S0008-4182(05)80050-X.


Case report: Primary intraocular lymphoma arose over a period of 9 months in the left eye of an 81-year-old woman who was blind in both eyes from temporal arteritis. During this period, she was treated with prednisone and methotrexate. Following a sudden total hyphema, the eye was enucleated. Examination revealed that, in addition to iris neovascularisation and central retinal artery occlusion, the neurosensory retina was replaced by atypical lymphocytes.

Comments: Histological and immunohistochemical studies confirmed the presence of a lymphoma with features indicative of an immunosuppression-related disorder. The relationship of the lymphoma to the vascular changes within the eye is discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Biomarkers, Tumor / metabolism
  • Biopsy
  • Eye Enucleation
  • Female
  • Giant Cell Arteritis / drug therapy*
  • Giant Cell Arteritis / pathology
  • Humans
  • Immunohistochemistry
  • Immunosuppressive Agents / adverse effects*
  • Lymphoma, B-Cell / chemically induced*
  • Lymphoma, B-Cell / metabolism
  • Lymphoma, B-Cell / pathology
  • Methotrexate / adverse effects*
  • Retinal Neoplasms / chemically induced*
  • Retinal Neoplasms / metabolism
  • Retinal Neoplasms / pathology


  • Biomarkers, Tumor
  • Immunosuppressive Agents
  • Methotrexate