Abstract
1. Triflusal is a salicylic derivative that inhibits platelet aggregation in human whole blood with a minimal inhibition of prostacyclin production. 2. Aspirin inhibits platelet aggregation at concentrations that reduce vascular prostacyclin production.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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6-Ketoprostaglandin F1 alpha / metabolism
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Arachidonic Acid / metabolism
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Aspirin / pharmacology*
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Blood Platelets / drug effects
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Blood Platelets / enzymology*
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Blood Platelets / metabolism
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Cyclooxygenase Inhibitors / pharmacology*
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Humans
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In Vitro Techniques
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Mesenteric Arteries / drug effects
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / enzymology*
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Muscle, Smooth, Vascular / metabolism
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Platelet Aggregation Inhibitors / pharmacology*
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Salicylates / pharmacology*
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Thromboxane B2 / biosynthesis
Substances
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Cyclooxygenase Inhibitors
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Platelet Aggregation Inhibitors
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Salicylates
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triflusal
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Arachidonic Acid
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Thromboxane B2
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6-Ketoprostaglandin F1 alpha
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Aspirin