Triflusal vs aspirin on the inhibition of human platelet and vascular cyclooxygenase

Gen Pharmacol. 1992 Mar;23(2):297-300. doi: 10.1016/0306-3623(92)90027-h.

Abstract

1. Triflusal is a salicylic derivative that inhibits platelet aggregation in human whole blood with a minimal inhibition of prostacyclin production. 2. Aspirin inhibits platelet aggregation at concentrations that reduce vascular prostacyclin production.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 6-Ketoprostaglandin F1 alpha / metabolism
  • Arachidonic Acid / metabolism
  • Aspirin / pharmacology*
  • Blood Platelets / drug effects
  • Blood Platelets / enzymology*
  • Blood Platelets / metabolism
  • Cyclooxygenase Inhibitors / pharmacology*
  • Humans
  • In Vitro Techniques
  • Mesenteric Arteries / drug effects
  • Muscle, Smooth, Vascular / drug effects
  • Muscle, Smooth, Vascular / enzymology*
  • Muscle, Smooth, Vascular / metabolism
  • Platelet Aggregation Inhibitors / pharmacology*
  • Salicylates / pharmacology*
  • Thromboxane B2 / biosynthesis

Substances

  • Cyclooxygenase Inhibitors
  • Platelet Aggregation Inhibitors
  • Salicylates
  • triflusal
  • Arachidonic Acid
  • Thromboxane B2
  • 6-Ketoprostaglandin F1 alpha
  • Aspirin