The prevalence of autistic spectrum disorder in children surveyed in a tertiary care epilepsy clinic

Epilepsia. 2005 Dec;46(12):1970-7. doi: 10.1111/j.1528-1167.2005.00343.x.


It is well documented that children with autistic spectrum disorder (ASD) have an increased prevalence of seizures; however, studies have not been done to evaluate the prevalence of ASD in children with epilepsy. This comorbidity is important to define as early diagnosis and intervention in some children with ASD has been shown to improve outcome.

Method: Children with epilepsy seen in a tertiary care epilepsy clinic were evaluated using validated autism screening questionnaires (ASQ). In addition, questions about sleep-related disorders, behavior, seizure characteristics, antiepileptic agents, and body mass index (BMI) were requested. An attempt was then made to determine if there was a correlation between the factors identified and ASD.

Results: Of the 107 questionnaires returned, 97 ASQ's were properly completed and used in this study. Approximately 32% of children fit the ASQ criteria for having ASD. Most children had not been previously diagnosed. Worst behavior and daytime sleepiness was seen in those at greater risk (p < 0.01). Seizures also occurred earlier (approximately 2 years) in children at risk of having ASD.

Conclusion: Though confirmatory diagnostic evaluations are needed, this questionnaire-based study suggests that children with epilepsy are at greater risk of having ASD, and illustrates the need for more clinical vigilance. Behavioral difficulties and daytime sleepiness identified in these children could potentially affect their ability to learn. It is of interest that the age of seizure onset identified in those at greater risk corresponds with the approximate age of regression identified in some children with ASD.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Age of Onset
  • Anticonvulsants / therapeutic use
  • Autistic Disorder / diagnosis
  • Autistic Disorder / epidemiology*
  • Autistic Disorder / psychology
  • Body Mass Index
  • Child
  • Child Behavior Disorders / diagnosis
  • Child Behavior Disorders / epidemiology
  • Child, Preschool
  • Comorbidity
  • Epilepsy / diagnosis
  • Epilepsy / epidemiology*
  • Female
  • Health Status
  • Hospitals, Pediatric / statistics & numerical data
  • Humans
  • Male
  • Mass Screening
  • Parents / psychology
  • Psychiatric Status Rating Scales / statistics & numerical data
  • Psychometrics
  • Regression, Psychology
  • Risk Factors
  • Sleep Wake Disorders / diagnosis
  • Sleep Wake Disorders / epidemiology
  • Surveys and Questionnaires


  • Anticonvulsants