Effect of a laxative with and without tegaserod in adolescents with constipation predominant irritable bowel syndrome

Aliment Pharmacol Ther. 2006 Jan 1;23(1):191-6. doi: 10.1111/j.1365-2036.2006.02705.x.

Abstract

Aim: To determine the effect of a laxative alone and in combination with tegaserod in alleviating pain and improving stool frequency in adolescents with constipation predominant irritable bowel syndrome.

Patients: Forty-eight postpubertal adolescents of both sexes with constipation predominant irritable bowel syndrome, as defined by Rome II criteria, were randomly allocated to Group A (n = 27) for treatment with a laxative (polyethylene glycol 3350 oral solution) only or Group B (n = 21) for combination therapy with the laxative and tegaserod. Symptoms of abdominal pain (scale 0-10) and frequency of bowel movements were recorded daily in the pre-treatment phase and the post-treatment phase after a 7-day 'washout' period. Patients served as their own controls.

Results: Treatment with the laxative alone (Group A) resulted in significant increase in frequency of bowel movements (P < 0.05), but not significant improvement in pain (P > 0.05). Treatment with the combination of the laxative and tegaserod (Group B) led to significant increase in the frequency of bowel movements and also significant reduction in pain (P < 0.05).

Conclusions: The laxative alone improved stooling but not pain in adolescents with constipation predominant irritable bowel syndrome. Addition of tegaserod resulted in alleviation of pain as well.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Abdominal Pain / diagnosis
  • Abdominal Pain / drug therapy
  • Adolescent
  • Cathartics / therapeutic use*
  • Constipation / complications
  • Constipation / drug therapy*
  • Drug Therapy, Combination
  • Female
  • Gastrointestinal Agents / therapeutic use*
  • Humans
  • Indoles / therapeutic use*
  • Irritable Bowel Syndrome / complications
  • Irritable Bowel Syndrome / drug therapy*
  • Male
  • Pain Measurement
  • Patient Satisfaction
  • Prospective Studies

Substances

  • Cathartics
  • Gastrointestinal Agents
  • Indoles
  • tegaserod