Isolation and chromosomal assignment of 100 highly informative human simple sequence repeat polymorphisms

Genomics. 1992 Jul;13(3):622-9. doi: 10.1016/0888-7543(92)90133-d.


One hundred highly informative simple sequence repeat (SSR) polymorphisms have been isolated and mapped to specific human chromosomes by somatic cell hybrid analysis. These markers include 97 (CA)n, 2 (AGAT)n, and a single (AACT)n repeat. All the SSRs have heterozygosities greater than 0.50 and can be amplified using identical PCR conditions. At least one SSR was detected on every chromosome, except for chromosomes 22 and Y. The frequency of (CA)n repeats on each chromosome was proportional to the relative chromosomal length, except for chromosome 15, on which a substantial excess of markers was identified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Chromosome Mapping
  • DNA / genetics
  • Genetic Markers
  • Heterozygote
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Repetitive Sequences, Nucleic Acid*


  • Genetic Markers
  • DNA

Associated data

  • GENBANK/M87670
  • GENBANK/M87671
  • GENBANK/M87672
  • GENBANK/M87673
  • GENBANK/M87674
  • GENBANK/M87675
  • GENBANK/M87676
  • GENBANK/M87677
  • GENBANK/M87678
  • GENBANK/M87679