Sequence of the human factor VIII-associated gene is conserved in mouse

Genomics. 1992 Jul;13(3):862-5. doi: 10.1016/0888-7543(92)90170-w.


cDNA and genomic clones corresponding to the human factor VIII-associated gene (F8A) were isolated from mouse cDNA and F8A-enriched genomic libraries. The sequences of these clones revealed an intronless gene coding for 380 amino acids, with 85% identity to the predicted human sequence. The single murine gene copy is genetically linked to factor VIII, but appears to lie outside the factor VIII gene by physical mapping. Like the human gene, the mouse F8A gene is highly expressed in a wide variety of tissues. This evolutionary comparison has helped to clarify the derived amino acid sequence in the human and strongly supports the hypothesis that the F8A gene encodes a protein.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biological Evolution
  • DNA / genetics
  • Factor VIII / genetics*
  • Genetic Linkage
  • Humans
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • Species Specificity


  • Factor VIII
  • DNA

Associated data

  • GENBANK/M83118
  • GENBANK/M84534
  • GENBANK/M84535
  • GENBANK/M84536
  • GENBANK/M84537
  • GENBANK/M84538
  • GENBANK/M84539
  • GENBANK/M84543
  • GENBANK/M84544
  • GENBANK/M91456