Chromatin, transcript elongation and alternative splicing

Nat Struct Mol Biol. 2006 Jan;13(1):5-7. doi: 10.1038/nsmb0106-5.

Abstract

A recent study reveals that the chromatin-remodeling factor SWI/SNF regulates alternative splicing by creating internal 'roadblocks' to transcriptional elongation where the phosphorylation status of RNA pol II is qualitatively changed.

Publication types

  • Comment
  • News

MeSH terms

  • Alternative Splicing / genetics*
  • Animals
  • Chromatin / genetics*
  • Humans
  • Kinetics
  • RNA Polymerase II / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic / genetics*

Substances

  • Chromatin
  • SMARCA2 protein, human
  • Transcription Factors
  • RNA Polymerase II