[The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis]

Orv Hetil. 2005 Nov 20;146(47):2409-14.
[Article in Hungarian]


The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis. Alcohol-induced liver disease is one of the main epidemic problems of nowadays. Non-alcoholic steatohepatitis has been described only for some years, but it also needs much more attention in the future. The etiologic factors of both entities are quite different, but the pathologic changes of the liver are nearly the same, therefore there could be certain drugs, that are equally effective in their therapy. Metadoxine is one of them, mainly because its protective effect against the damage done by free radicals. Metadoxine is a pyridoxine-pyrrolidone carboxylate with significant scavenging property. There are a lot of patients suffering from steatohepatitis, and they will face the complications of the liver damage. The aim is to provide better recovery and proper quality of life, which is based on the deeper understanding of these mechanisms. Metadoxine is suitable for increasing reduced glutathione level, which is very important for the redox homeostasis of the liver and the whole body. The effectiveness of the drug is established both in acute and in chronic alcoholism, moreover it helps in staying abstinent.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Alcohol Deterrents / therapeutic use*
  • Alcoholic Intoxication / drug therapy
  • Alcoholism / complications
  • Alcoholism / drug therapy*
  • Drug Combinations
  • Fatty Liver / drug therapy*
  • Fatty Liver, Alcoholic / drug therapy
  • Glutathione / metabolism
  • Hepatitis / drug therapy
  • Hepatitis, Alcoholic / drug therapy*
  • Humans
  • Pyridoxine / therapeutic use*
  • Pyrrolidonecarboxylic Acid / therapeutic use*
  • Quality of Life


  • Alcohol Deterrents
  • Drug Combinations
  • metadoxine
  • Glutathione
  • Pyridoxine
  • Pyrrolidonecarboxylic Acid