Future uses of mesenchymal stem cells in spine surgery

Neurosurg Focus. 2005 Dec 15;19(6):E13. doi: 10.3171/foc.2005.19.6.14.


Stem cells are currently being studied for use in numerous clinical applications, ranging from neurodegenerative diseases to cardiac insufficiency. The use of mesenchymal stem cells (MSCs) in spine surgery is also compelling, especially with the increasing age of the general population. In this review the authors discuss the use of MSCs for intervertebral disc repair and regeneration and for use in spinal arthrodesis procedures. Clearly, the routine use of cellular therapies by spine surgeons to improve outcome after a variety of surgical procedures is rapidly approaching.

Publication types

  • Review

MeSH terms

  • Bone Regeneration / physiology
  • Diskectomy / methods
  • Diskectomy / trends
  • Humans
  • Intervertebral Disc Displacement / physiopathology
  • Intervertebral Disc Displacement / surgery
  • Mesenchymal Stem Cell Transplantation / methods
  • Mesenchymal Stem Cell Transplantation / trends*
  • Mesenchymal Stem Cells / physiology
  • Neurosurgical Procedures / methods
  • Neurosurgical Procedures / trends*
  • Spinal Diseases / pathology
  • Spinal Diseases / physiopathology
  • Spinal Diseases / surgery*
  • Spinal Fusion / methods
  • Spinal Fusion / trends
  • Spine / pathology
  • Spine / physiopathology
  • Spine / surgery*