Mechanisms of mechanotransduction

Dev Cell. 2006 Jan;10(1):11-20. doi: 10.1016/j.devcel.2005.12.006.


Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces regulate a large array of physiological processes, and dysregulation of mechanical responses contributes to major human diseases. A survey of both specialized and widely expressed mechanosensitive systems suggests that physical forces provide a general means of altering protein conformation to generate signals. Specialized systems differ mainly in having acquired efficient mechanisms for transferring forces to the mechanotransducers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / physiology*
  • Animals
  • Cell Cycle / physiology
  • Humans
  • Hypertension / pathology
  • Hypertension / physiopathology
  • Lung / physiology
  • Mechanotransduction, Cellular / physiology*
  • Models, Biological
  • Muscle, Smooth, Vascular / physiopathology
  • Myocardium
  • Neoplasms / physiopathology
  • Physical Stimulation
  • Protein Structure, Tertiary / physiology
  • Signal Transduction / physiology*
  • Stress, Mechanical