Gastric bypass and resolution of proteinuria in an obese diabetic patient

Diabet Med. 2005 Dec;22(12):1761-2. doi: 10.1111/j.1464-5491.2005.01679.x.


There is few human studies evidence that suggest a role for obesity in the formation and progression of glomerular lesions. We report the case of a morbidly obese female with diabetic nephropathy that was subsequently diagnosed with renal failure. Proteinuria resolved after gastric bypass procedure. The reduction of glomerular hyperfiltration and blood pressure associated with the important weight loss may be the major contributors to the decrease of proteinuria and serum creatinine levels in our patient.

Publication types

  • Case Reports

MeSH terms

  • Blood Pressure / physiology
  • Creatinine / blood
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / surgery*
  • Diabetic Nephropathies / complications*
  • Diabetic Nephropathies / surgery
  • Female
  • Gastric Bypass*
  • Humans
  • Middle Aged
  • Obesity, Morbid / complications
  • Obesity, Morbid / surgery*
  • Proteinuria / etiology*
  • Proteinuria / surgery
  • Weight Loss / physiology


  • Creatinine