Autologous peripheral blood stem cell transplantation for POEMS syndrome

Neurology. 2006 Jan 10;66(1):105-7. doi: 10.1212/01.wnl.0000188757.38495.23.

Abstract

Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes syndrome is a rare multisystem disorder. Overproduction of vascular endothelial growth factor (VEGF) by plasmocytoma could be responsible for the symptoms. The authors treated four patients with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. Within 6 months, symptoms associated with rapid normalization of serum VEGF levels improved.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Down-Regulation / drug effects
  • Down-Regulation / physiology
  • Female
  • Hematopoietic Stem Cell Transplantation / methods*
  • Humans
  • Male
  • Melphalan / therapeutic use*
  • Middle Aged
  • Myeloablative Agonists / therapeutic use*
  • POEMS Syndrome / physiopathology
  • POEMS Syndrome / therapy*
  • Peripheral Nervous System Diseases / drug therapy
  • Peripheral Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / physiopathology
  • Plasmacytoma / complications
  • Plasmacytoma / drug therapy
  • Plasmacytoma / metabolism
  • Transplantation, Autologous
  • Treatment Outcome
  • Vascular Endothelial Growth Factor A / blood
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Myeloablative Agonists
  • Vascular Endothelial Growth Factor A
  • Melphalan