G-protein-coupled receptors: past, present and future

Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S27-37. doi: 10.1038/sj.bjp.0706455.


The G-protein-coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have therapeutic actions across a wide range of human diseases ranging from allergic rhinitis to pain, hypertension and schizophrenia. This review provides a brief historical overview of the properties and signalling characteristics of this important family of receptors.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Ligands
  • Radioligand Assay
  • Receptors, G-Protein-Coupled / drug effects
  • Receptors, G-Protein-Coupled / history*
  • Receptors, G-Protein-Coupled / physiology
  • Signal Transduction


  • Ligands
  • Receptors, G-Protein-Coupled