Double-echo perfusion-weighted MR imaging: basic concepts and application in brain tumors for the assessment of tumor blood volume and vascular permeability

Eur Radiol. 2006 Jan;16(1):180-6. doi: 10.1007/s00330-005-2807-9. Epub 2005 Jun 14.


Perfusion-weighted magnetic resonance (MR) imaging using contrast agents plays a key role in characterizing tumors of the brain. We have shown that double-echo perfusion-weighted MR imaging (DEPWI) is potentially useful in assessing brain tumors. Quantitative indices, such as tumor blood volume, are obtained using DEPWI, which allows correction of underestimation of tumor blood volume due to leakage of contrast agents from tumor vessels, in addition to simultaneous acquisition of tumor vessel permeability. This article describes basic concepts of DEPWI and demonstrates clinical applications in brain tumors.

Publication types

  • Review

MeSH terms

  • Blood Volume / physiology*
  • Brain / pathology*
  • Brain Neoplasms / blood supply*
  • Brain Neoplasms / metabolism
  • Brain Neoplasms / physiopathology*
  • Capillary Permeability / physiology*
  • Cerebrovascular Circulation
  • Contrast Media / administration & dosage
  • Gadolinium DTPA / administration & dosage
  • Humans
  • Image Enhancement / methods
  • Magnetic Resonance Angiography / methods*
  • Time Factors


  • Contrast Media
  • Gadolinium DTPA