A review of antioxidants and Alzheimer's disease

Ann Clin Psychiatry. Oct-Dec 2005;17(4):269-86. doi: 10.1080/10401230500296428.

Abstract

Background: In this article, we review a diverse body of research and draw conclusions about the usefulness, or lack there-of, of specific antioxidants in the prevention of Alzheimer's disease (AD).

Methods: The National Library of Medicine's database was searched for the years 1996-2004 using the search terms "Alzheimer's, anti-oxidants, antioxidants."

Results: Over 300 articles were identified and 187 articles were selected for inclusion based on relevance to the topic. Agents that show promise in helping prevent AD include: 1) aged garlic extract, 2) curcumin, 3) melatonin, 4) resveratrol, 5) Ginkgo biloba extract, 6) green tea, 7) vitamin C and 8) vitamin E.

Conclusions: While the clinical value of antioxidants for the prevention of AD is often ambiguous, some can be recommended based upon: 1) epidemiological evidence, 2) known benefits for prevention of other maladies, and 3) benign nature of the substance. Long-term, prospective studies are recommended.

Publication types

  • Review

MeSH terms

  • Acetylcarnitine / therapeutic use
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / prevention & control*
  • Antioxidants / therapeutic use*
  • Ascorbic Acid / therapeutic use
  • Brain / physiopathology
  • Coumaric Acids / therapeutic use
  • Ginkgo biloba
  • Humans
  • Lipid Peroxidation / physiology
  • Melatonin / therapeutic use
  • Nerve Degeneration / physiopathology
  • Oxidative Stress
  • Panax
  • Phytotherapy / methods
  • Thioctic Acid / therapeutic use
  • Vitamin E / therapeutic use

Substances

  • Antioxidants
  • Coumaric Acids
  • Vitamin E
  • Acetylcarnitine
  • Thioctic Acid
  • ferulic acid
  • Melatonin
  • Ascorbic Acid