Blood-brain barrier permeability in "healthy" infected and stressed neonates

J Pediatr. 1992 Aug;121(2):291-4. doi: 10.1016/s0022-3476(05)81207-7.


The assessment of the blood-brain barrier permeability (BBBP) showed that BBBP values were higher in stressed neonates and those with bacterial meningitis than in "healthy" infants or neonates with aseptic meningitis. The BBBP determination may be helpful in differentiating bacterial from aseptic meningitis; the high BBBP should be considered in the management of stressed neonates.

MeSH terms

  • Asphyxia Neonatorum / physiopathology
  • Blood-Brain Barrier / physiology*
  • Diagnosis, Differential
  • Heart Defects, Congenital / physiopathology
  • Humans
  • Infant, Newborn / physiology*
  • Meningitis, Aseptic / diagnosis
  • Meningitis, Aseptic / physiopathology*
  • Meningitis, Bacterial / diagnosis
  • Meningitis, Bacterial / physiopathology*
  • Permeability
  • Stress, Physiological / physiopathology*