Randomized, controlled trial of antibiotic therapy for Escherichia coli O157:H7 enteritis

J Pediatr. 1992 Aug;121(2):299-303. doi: 10.1016/s0022-3476(05)81209-0.


We undertook a prospective, controlled study to evaluate the effect of trimethoprim-sulfamethoxazole in children with proven Escherichia coli O157:H7 enteritis on the duration fo symptoms, on fecal excretion of pathogen, and on the risk of progression to hemolytic-uremic syndrome. There was no statistically significant effect of treatment on progression of symptoms, fecal pathogen excretion, or the incidence of HUS (2/22 vs 4/25; p = 0.67). Our results suggest that a multicentric trial using rapid diagnostic methods to permit early randomization should be carried out.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Child
  • Child, Preschool
  • Enteritis / drug therapy*
  • Enteritis / microbiology
  • Escherichia coli / classification
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / complications
  • Escherichia coli Infections / drug therapy*
  • Feces / microbiology
  • Female
  • Hemolytic-Uremic Syndrome / etiology
  • Humans
  • Infant
  • Male
  • Prospective Studies
  • Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use*


  • Trimethoprim, Sulfamethoxazole Drug Combination