Structure and function of matrix metalloproteinases and TIMPs

Cardiovasc Res. 2006 Feb 15;69(3):562-73. doi: 10.1016/j.cardiores.2005.12.002. Epub 2006 Jan 5.


Matrix metalloproteinases (MMPs), also called matrixins, function in the extracellular environment of cells and degrade both matrix and non-matrix proteins. They play central roles in morphogenesis, wound healing, tissue repair and remodelling in response to injury, e.g. after myocardial infarction, and in progression of diseases such as atheroma, arthritis, cancer and chronic tissue ulcers. They are multi-domain proteins and their activities are regulated by tissue inhibitors of metalloproteinases (TIMPs). This review introduces the members of the MMP family and discusses their domain structure and function, proenyme activation, the mechanism of inhibition by TIMPs and their significance in physiology and pathology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / enzymology
  • Cardiovascular System / enzymology*
  • Extracellular Matrix / enzymology*
  • Humans
  • Matrix Metalloproteinase Inhibitors
  • Matrix Metalloproteinases / chemistry*
  • Structure-Activity Relationship
  • Tissue Inhibitor of Metalloproteinases / chemistry*
  • Tissue Inhibitor of Metalloproteinases / metabolism


  • Matrix Metalloproteinase Inhibitors
  • Tissue Inhibitor of Metalloproteinases
  • Matrix Metalloproteinases