APOBEC3 cytidine deaminases: distinct antiviral actions along the retroviral life cycle

J Biol Chem. 2006 Mar 31;281(13):8309-12. doi: 10.1074/jbc.R500021200. Epub 2005 Dec 30.

Abstract

The field of human immunodeficiency virus (HIV) biology has been galvanized by the discovery of innate APOBEC3 cytidine deaminases, which pose powerful barriers to the replication of HIV and other retroviruses. Rapid progress has been made in defining their action, intriguing regulation within cells, expanded range of retroviral targets, and counterstrikes utilized by retroviruses against them. Although scientifically fascinating, advances in APOBEC3 biology may lead to new antiviral drugs and improved lentiviral vectors for gene therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / pharmacology*
  • Cytidine Deaminase / metabolism*
  • Cytosine Deaminase / metabolism*
  • Humans
  • Models, Biological
  • Retroviridae / drug effects*
  • Retroviridae / genetics

Substances

  • Antiviral Agents
  • Cytosine Deaminase
  • APOBEC3 protein, human
  • Cytidine Deaminase