Characterization of the cDNA Encoding alphaIIb and beta3 in normal horses and two horses with Glanzmann thrombasthenia

P W Christopherson; T A Insalaco; V L van Santen; L Livesey; C Bourne; M K Boudreaux

doi:10.1354/vp.43-1-78

Characterization of the cDNA Encoding alphaIIb and beta3 in normal horses and two horses with Glanzmann thrombasthenia

Vet Pathol. 2006 Jan;43(1):78-82. doi: 10.1354/vp.43-1-78.

Authors

P W Christopherson¹, T A Insalaco, V L van Santen, L Livesey, C Bourne, M K Boudreaux

Affiliation

¹ Department of Pathobiology, 166 Greene Hall, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.

PMID: 16407493
DOI: 10.1354/vp.43-1-78

Abstract

Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin alpha(IIb)beta3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.

Publication types

Comparative Study

MeSH terms

Animals
Base Sequence
DNA Primers
DNA, Complementary / genetics*
Horse Diseases / genetics*
Horses
Integrin beta3 / genetics*
Molecular Sequence Data
Platelet Membrane Glycoprotein IIb / genetics*
Sequence Analysis, DNA / veterinary
Thrombasthenia / genetics
Thrombasthenia / veterinary*

Substances

DNA Primers
DNA, Complementary
Integrin beta3
Platelet Membrane Glycoprotein IIb