Chemical biology at the crossroads of molecular structure and mechanism

Nat Chem Biol. 2005 Nov;1(6):300-3. doi: 10.1038/nchembio1105-300.


Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function.

Publication types

  • Review

MeSH terms

  • Biochemistry / methods*
  • Crystallography, X-Ray
  • Molecular Biology / methods*
  • Molecular Conformation
  • RNA / chemistry
  • RNA / metabolism
  • Structure-Activity Relationship


  • RNA