Chemical biology at the crossroads of molecular structure and mechanism

Jennifer A Doudna

doi:10.1038/nchembio1105-300

Chemical biology at the crossroads of molecular structure and mechanism

Nat Chem Biol. 2005 Nov;1(6):300-3. doi: 10.1038/nchembio1105-300.

Author

Jennifer A Doudna¹

Affiliation

¹ Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94705, USA. doudna@berkeley.edu

PMID: 16408062
DOI: 10.1038/nchembio1105-300

Abstract

Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function.

Publication types

Review

MeSH terms

Biochemistry / methods*
Crystallography, X-Ray
Molecular Biology / methods*
Molecular Conformation
RNA / chemistry
RNA / metabolism
Structure-Activity Relationship

Substances

RNA